Scientific Evidence

Nurosym is pioneering a new class of technology that uses bioelectrical signals targeted to neural circuits of organs, treating disease without surgery or drugs.

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Nurosym at a Glance

Groundbreaking

First CE-Marked non-invasive vagal neuromodulation system

Innovative Investment

$10M invested in clinical research with patented Nurosym technology

Milestone Achievement

Over 4 million treatment sessions successfully completed

Scientific Validation

More than 50 peer-reviewed clinical study publications on Nurosym

Extensive Collaboration

Collaborating with over 60  world-class research partners

Robust Exploration

Over 60 ongoing clinical trials underway

Vagus Nerve Activity

67% increase in 5 minutes
Vagus Nerve Activity

90% increase after 2 mo.
Anxiety

35% reduction
Long-Covid Symptoms

61% reduction
Fatigue

48% reduction
Sleep

19% improvement
Inflammation

78% reduction
Depression Symptoms

45% reduction
Heart Rate Variability

18% increase
POTS Tachycardia

40% reduction
Oxidative Stress

28% reduction
Memory

32% improvement
Reading

28% improvement
Attention Deficiency

11% reduction
Macrocirculation

50% improvement
Microcirculation

39% improvement
Blood Pressure

10% reduction
Results in specific study populations. Individual results may vary.

Nurosym Results from 50+ Clinical Trials

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How does Nurosym Work

The Mechanisms of Nurosym Neuromodulation

Nurosym sends patented electrical impulses to the brain via the Vagus Nerve, which leads to:

61% increase in Vagus Nerve Activity & improved Heart Rate Variability

Stress Management Depression & Anxiety Reduction Sleep Quality Exercise Recovery Anti-ageing & Longevity Autonomic Balance

The parasympathetic nervous system is the body’s internal relaxation & rest mechanism. HRV is an indicator of Vagus Nerve activity. Improving these parameters of HRV indicates targeted stimulation of the vagus nerve and activation of psychophysiological self-repair mechanisms. In a clinical trial, a one-hour session of Nurosym favourably altered all parameters of Heart Rate Variability (HRV), when compared to a placebo. Figure (A) shows High Frequency HRV is significantly increased (*p=0.001). Figure (B) shows Low Frequency HRV is significantly decreased (*P=0.001). Figure (C) shows the ratio of LF to HF is significantly decreased (*p=0.002).

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in the Cardiovascular and Translational Research and the PLOS ONE journals.

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35% reduction in Anxiety Symptoms

Stress Management Anxiety Relief Insomnia Resilience Performance Inflammation Control Cortisol Control

Studies have demonstrated that pre-existing symptoms such as anxiety further heighten the risk of symptoms associated with chronic inflammation. Research on the Nurosym neuromodulation system has shown that it activates the vagus nerve, leading to a reduction in anxiety and stress responses. This targeted stimulation of the vagus nerve increases vagal tone and inhibits cytokine production in the inflammatory process. Both are important mechanisms for anxiety resilience.The figure illustrates changes in anxiety across three timepoints: pre-intervention (D0), post-intervention (D10) (D0 vs D10, p < 0.001), and 1-month follow-up after accomplished therapy (D0 vs Follow-up, p < 0.001).

Source:

One-group assignment study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in the Frontiers in Neurology Journal

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48% reduced Fatigue & increased Energy

Productivity Social Functioning Brain Fog Reduction Sleep Quality Pain Relief Long-Covid Symptoms Ageing & Longevity

Nurosym neuromodulation has demonstrated a beneficial effect on fatigue by modulating the autonomic nervous system, leading to enhanced energy levels and reduced sensations of exhaustion. In the study, patients reported sustained improvements even one week after discontinuing the therapy, indicating prolonged relief from fatigue-related symptoms.(Figure) Fatigue was assessed using the Pichot fatigue scale scores during therapy (D0: day 0, D5: day 5 and D10: day 10). The results revealed a substantial reduction in fatigue, registering approximately 48% improvement (D0 vs. D10, p < 0.0001) after Nurosym neuromodulation theraphy.

Source:

Clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in the Advances in Neurology and Neuroscience Journal

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19% improvement in Sleep Scores

Insomnia Reduction Fatigue Improvement, Immune Function Metabolic Health Memory Ageing & Longevity

In individuals with sleep onset difficulties, the sympathetic branch of the autonomic nervous system may exhibit heightened activity compared to the parasympathetic branch, resulting in increased agitation. The study demonstrated that Nurosym neuromodulation enhances parasympathetic activity, which in turn mitigates agitation and improves sleep scores.(Figure) Changes in sleep (PROMIS Sleep Disturbance) across three timepoints: pre-intervention, post-intervention, and 1-month follow-up (*p < 0.05).

Source:

One-group assignment study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in the Frontiers in Neurology Journal

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61% improved Brain Fog, Gastrointestinal Function & Pain (Long Covid Symptoms)

Chronic Fatigue Syndrome (ME/CFS) Stress & Anxiety Management Mental Health Athletic Recovery Productivity Respiratory Improvement Gastrointestinal & IBS Control

A growing body of research suggests that vagus nerve regulation plays a crucial role in managing chronic inflammation. Nurosym, through the stimulation of afferent vagus nerve fibres, has been shown to influence higher brain structures. This modulation may help alleviate symptoms connected to Long-Covid Syndrome such as chronic fatigue, pain, and brain fog.(Figure ) A very significant improvement in Long-COVID symptoms was observed after 10 neuromodulation therapy sessions. (D0 vs. D10: p < 0.0001).

Source:

Clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Advances in Neurology and Neuroscience

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45% improvement in Depression Score & Improved Mood

Cognitive Improvement Mood Stabilisation Stress Resilience Brain Fog Sleep Quality: Post-Traumatic Recovery

Disruption of signals in the afferent fibres of the vagus nerve can directly or indirectly induce brain disorders, including depression. Nurosym neuromodulation significantly decreased depression scores and improved mood within just 5 days of therapy, with continued improvement observed after 10 days.(Figure) The figure shows the evolution of the Beck depression scale (D0: day 0, D5: day 5 and D10: day 10). The results showed a noticeable improvement in mood, registering approximately 45% on the Beck Depression Scale (p<0.05).

Source:

Clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Advances in Neurology and Neuroscience

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11% improvement in Attention Deficiency Symptoms

Attention and Focus Behavioral Regulation Impulse Control Executive Function Emotional Regulation Social Interaction

Individuals with attention deficits, including those diagnosed with ADHD, often exhibit low heart rate variability (HRV) measurements, indicating reduced vagus nerve activity and diminished parasympathetic tone. Nurosym neuromodulation counteracts the persistent sympathetic "fight-or-flight" overdrive, thereby enhancing cognitive function.(Figure) Changes in attention were assessed using the Flanker Inhibitory Control and Attention assay across three timepoints: pre-intervention, post-intervention, and 1-month follow-up. After Nurosym therapy, significant gains were detected from pre-intervention to post-intervention (p < 0.01) and from pre-intervention to follow-up (p < 0.001).

Source:

One-group assignment study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in the Frontiers in Neurology Journal

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40% reduction in POTS Symptoms

Heart Rhythm Arrhythmias & Palpitations Control Dizziness Reduction Cardiovascular Health Exercise Tolerance Immune Function

People who suffer from POTS or tachycardia have diminished size vagus nerves. Research team discovered that POTS symptoms were significantly lessened in people receiving Nurosym — 15 beats less per minute compared to the placebo group. Additionally, the active group showed lower levels of anti-autonomic autoantibodies (specifically α1-AR and β1-AR)(Figure) Comparison of Orthostatic Tachycardia between Nurosym neuromodulation and placebo stimulation after a 2-Month. The figure illustrates the changes in heart rate upon standing.

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in the Journal of the American College of Cardiology

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28% reduction in Oxidative Stress (Reactive Oxygen Species)

Aging & Longevity Inflammatory Processes Antioxidant Defense Cellular & Mitochondrial Function Oxidative Stress Markers Cortisol Levels

Biologically, the vagus nerve inhibits oxidative stress, inflammation and sympathetic activity (and associated hypoxia). Nurosym led to a significant decrease in reactive oxygen species (ROS) (p = 0.004), while placebo stimulation did not cause a significant change (p = 0.10).(Figure) Change in median DCF values from admission to discharge in the Nurosym group compared to the placebo group (p < 0.005).

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in the Clinical Autonomic Research Journal

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61% improvement in Inflammation

Inflammatory Processes Aging & Longevity Muscle Pain Chronic Pain Cardiac Conditions (AF, HF, Hypertension) Mental Health Autoimmune Disorders IBS & Other GI Symptoms

Inflammation throughout the body and brain contributes to disease development, progression, ageing, and mental health problems. In a randomised controlled trial of Nurosym neuromodulation, inflammatory cytokines were significantly lower in the group that received Auricular Vagal Neuromodulation Therapy (AVNT) compared to the placebo group at the end of 3 months.(Figure) The figure presents the changes in the IL-6 inflammatory biomarker compared to placebo.

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Clinical Autonomic Research and the Journal of American Heart Association. Reviewed in Nature Reviews Cardiology.

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29% improvement in Reading and Learning

Cognitive Enhancement Alzheimer’s & Dementia Brain Fog Mood Improvement Ageing & Longevity Social Functioning

Researchers have demonstrated a direct link between vagus nerve stimulation and the activation of learning centres in the brain. This discovery has led to the evaluation of Nurosym neuromodulation, which has been shown to enhance cognitive retention in both healthy individuals and those with injured nervous systems.(Figure) Nurosym neuromodulation paired with training significantly (*p < 0.05) improved speed performance on the Automaticity learning task compared to placebo controls. Nurosym neuromodulation also significantly (∗p < 0.05) improved percent correct on the Decoding learning task as compared to controls.

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Brain Stimulation

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32% improvement in Memory Recall

Productivity Problem-Solving Skills Alzheimer’s & Dementia Cognitive Enhancement & Performance Social Functioning Memory function Post-Traumatic Recovery

The vagus nerve, through its physiological connections to various brain areas, plays a key role in modulating many behavioural processes related to memory. Nurosym research investigates enhancements in memory and neuroplasticity, linking cognitive function with the parasympathetic nervous system.(Figure A, B) Nurosym improves memory on learning tasks in comparison to placebo. (A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Brain Stimulation

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85% reduction in Atrial Fibrillation Burden

Performance Productivity & Energy Reduced Cardiovascular Risks Cognitive Function Reduced Pain Arrhythmias Control Autonomic Balance

The vagus nerve modulates the inflammatory response, thereby reducing the systemic inflammatory burden that contributes to the progression of various diseases, including atrial fibrillation. Leveraging this mechanism, Nurosym neuromodulation offers a non-invasive modality for regulating cardiac rhythm, effectively suppressing atrial fibrillation.(Figure) Comparison of atrial fibrillation (AF) burden between the two groups (Nurosym neuromodulation vs Placebo stimulation) is presented using interquartile range values. The p-value reflects the comparison of median AF burden levels at the 6-month mark, adjusted for baseline measurements.

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in The Journal of Cardiovascular Translational Research

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19% improvement of Heart Muscle Function (Global Longitude Strain reduction)

Heart Function Performance Productivity & Energy Reduced Heart Failure Risk Cardiovascular Improvement

Many studies have shown that drug treatments do not improve morbidity and mortality in patients after myocardial infarction. These patients often exhibit significant autonomic dysfunction, characterised by increased sympathetic nervous system activity and decreased parasympathetic (vagal) activity. The study found that Nurosym is effective by targeting cardiac inflammation and autonomic dysfunction.(Figure) Comparison of the effect of Nurosy neuromodulation on global longitudinal strain (GLS) during active versus placebo stimulation. Active neuromodulation resulted in a significant improvement in GLS (p = 0.001) compared to sham stimulation.

Source:

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50% improvement in Blood Vessel Flexibility & improved Circulation (FMD)

Blood Clots Risk Reduction Endothelial Function Peripheral Vascular Control Cognitive Enhancement Improved Metabolism Fatigue Reduction

The purpose of the study was to determine the influence of vagal innervation control of the resting diameter of large blood vessels using Nurosym neuromodulation. Nurosym has demonstrated a significant ability to enhance blood circulation and macrovascular endothelial function compared to a placebo.(Figure) Percent change in flow-mediated vasodilation (FMD) with Nurosym. "Before" and "after" refer to the brachial artery (BA) diameter and FMD test conducted pre- and post-Nurosym neuromodulation. The y-axis shows the percent change in BA diameter. The box shows the 25th–75th percentile, the middle line is the median, the dot is the mean, and the bars indicate the maximum and minimum values.

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in The Journal of Cardiac Failure

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39% improvement in markers of Microcirculatory Function

Cardiovascular Health Varicose Veins Organ Function Cognitive Enhancement Improved Metabolism Oxygen and nutrient delivery to tissues

Parasympathetic outflow utilises the circuit from the dorsal motor nucleus of the vagus nerve to regulate circulation. This improvement in blood circulation, or perfusion rate, is crucial for efficiently supplying oxygen and nutrients to tissues while removing waste products. The study using Nurosym indicated a trend towards enhanced microcirculatory function,(Figure) (A) Changes in blood perfusion measured over nail bed area, before and after Nurosym neuromodulation (B) and sham (placebo) stimulation (C). Markedly higher perfusion rate was seen after Nurosym neuromodulation

Source:

Randomised, placebo controlled clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in The Journal of Cardiac Failure

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10% Reduction in Blood Pressure

Reduced Cardiovascular Risk Systolic and Diastolic Control Reduced Stress Markers Cardiovascular Efficiency Quality of Life

Nurosym reduced systolic blood pressure (SBP) by approximately 9.7% and diastolic blood pressure (DBP) by 10.2% over three months in young adults with Grade 1 hypertension. Additionally, it significantly reduced stress markers and stabilised cardiovascular function by reducing vascular resistance without altering heart rate. Patients also reported improved quality of life, highlighting the intervention’s broader benefits.

Source:

A randomised clinical trial using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in the Journal of the American Heart Association.

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Meet the Doctors

Dr. Elisabetta Burchi, MD, MBA

Translational research lead at Parasym

A practicing doctor of psychiatry, Elisabetta has an MBA from INSEAD Business School, and experience in direct patient care, neuroscience research, communication and management. Dr. Burchi is a physician-scientist, working with Parasym in clinical affairs with a track record of publishing in the most important scientific journals such as The Lancet, writing successful grant proposals for the NIH, and leading the production of editorial, clinical, regulatory and promotional material in collaborative multidisciplinary teams. Dr. Burchi has also coordinated clinical trials and implemented a tele-medicine practice which received a certification of excellence among more than 100,000 professionals.

Real Experiences

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50+

Ongoing clinical studies

4M+

Happy patient sessions

Day money back guarantee

Certified medical device

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Scientific Evidence

Nurosym at a Glance

Groundbreaking

Innovative Investment

Milestone Achievement

Scientific Validation

Extensive Collaboration

Robust Exploration

Vagus Nerve Activity

Vagus Nerve Activity

Anxiety

Long-Covid Symptoms

Fatigue

Sleep

Inflammation

Depression Symptoms

Heart Rate Variability

POTS Tachycardia

Oxidative Stress

Memory

Reading

Attention Deficiency

Macrocirculation

Microcirculation

Blood Pressure

Nurosym Results from 50+ Clinical Trials

30 Day Money-Back Guarantee

The Mechanisms of Nurosym Neuromodulation

61% increase in Vagus Nerve Activity & improved Heart Rate Variability

35% reduction in Anxiety Symptoms

48% reduced Fatigue & increased Energy

19% improvement in Sleep Scores

61% improved Brain Fog, Gastrointestinal Function & Pain (Long Covid Symptoms)

45% improvement in Depression Score & Improved Mood

11% improvement in Attention Deficiency Symptoms

40% reduction in POTS Symptoms

28% reduction in Oxidative Stress (Reactive Oxygen Species)

61% improvement in Inflammation

29% improvement in Reading and Learning

32% improvement in Memory Recall

85% reduction in Atrial Fibrillation Burden

19% improvement of Heart Muscle Function (Global Longitude Strain reduction)

50% improvement in Blood Vessel Flexibility & improved Circulation (FMD)

39% improvement in markers of Microcirculatory Function

10% Reduction in Blood Pressure

Are you a healthcare professional?

Meet the Doctors

Dr. Elisabetta Burchi, MD, MBA

Patient Stories

Collaborate with us

Ask your Doctor about Nurosym

Are you a healthcare professional?

Cutting edge Neuromodulation

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